Allergan’s new toxin, Boey, got its European approval on July 17, 2026. Dazed called it “try before you buy” Botox in October. The FDA has not approved it.
My read, mostly in words I have already said about toxin.
The Molecule
“Boey (trenibotulinumtoxinE) is a serotype E toxin, which is a different family from Botox and the other type A products.”
Onset as early as eight hours in the trials. Gone in about two to three weeks. Approved in Europe for frown lines in adults.
Who Walks In for It
“Most people who stay away from toxin are not afraid of the needle. They are afraid of looking frozen or wrong for four months.”
We already use toxin as a preview in my practice. “Well, if you’re happy with what you get with Botox, you’re probably gonna be happy with what you get with Quantum. And it’s worth a try.”
Boey makes the preview the product.
Who Should Not Bother
The patient who already likes her toxin. Mine is on a schedule.
“I myself get botulinum toxin in the forehead, crow’s feet, and glabella lines every three to four months, just to maintain the wrinkle free appearance with a dose that still lets me express my face without looking abnormal. I believe the skin quality in these areas is also maintained with the use of botulinum toxin.”
“It really is a maintenance therapy.”
“Patients really like the results, and that’s why they keep coming back to get the botulinum toxin injections.”
“I think Botox is something you just kind of have to keep doing, because it gives us the best result for this area.”
Two weeks, for that patient, is a visit every few weeks.
How Long Toxin Lasts Already Varies
“I see very active patients, runners and high-intensity athletes, tend to come back for Botox in about two and a half to three months. At the same time, I see my more sedentary, less active patients at four months.”
“Although there is no scientific study to explain this, there are a few theories. One is a higher resting metabolism, which of course increases blood flow throughout the body, including the facial muscles, especially during strenuous exercise.”
What Decides the Face
Not the serotype.
“Dose, dilution, injection placement, and product choice matter more than whether you are active or inactive. These are all customized depending on each patient’s consultation. For example, patients with very strong frontalis muscles, glabellar muscles, or masseters will require a higher dose than others.”
The trial side effects in Europe were eyelid ptosis, brow ptosis and Mephisto sign. Same list as type A.
“We see a good number of patients where the botulinum toxin is incorrectly applied resulting in eyelid droopiness, brow droopiness, and uneven smiles.”
“I do ask patients not to exercise for twenty-four hours after a botulinum toxin injection, but this is not because it is going to wear off sooner. It is because I want the solution to stay exactly where I injected it, and strenuous exercise immediately after an injection could increase the risk of the product migrating, complications, and swelling.”
Same argument I made about the frozen forehead in my read of the Megan Fox photos.
The Gray Market
Any Boey offered in the US today did not come through an approved channel. More in the counterfeit toxin commentary.
“The danger with counterfeit products is that we only find out because they go to the ED because of severe life threatening complications. Some counterfeit products result in no result at all because they do not contain the botulinum toxin.”
“We buy directly from the manufacturers, Galderma, Allergan, and Evolus. The toxin is shipped to us directly from them in temperature controlled containers.”
“We do not use a middle man or discount pharmacy to order our toxins.”
My Bottom Line
“This doesn’t mean that it’s the safest bet; it means that it’s something that’s tried and proven.” That was about type A. Boey has two trials behind it and no US approval. A trial run, if it ever gets here.
The med spa version is on the Southwest Plastic Surgery site, and the first-timer’s guide is on agulloplasticsurgery.com. Type A toxin is at Agullo Plastic Surgery and the MedSpa. I trained at the Mayo Clinic and teach at Texas Tech University Health Sciences Center Paul L. Foster School of Medicine.
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Call (915) 590-7900, text 1-866-814-0038, or book online at agulloplasticsurgery.com. #StayBeautiful
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